| No. | Item | Definition |
|---|---|---|
| 1. | adversity | a state of hardship |
| 2. | affliction | something causing pain or trouble |
| 3. | aggravation | trouble causing irritation |
| 4. | albatross | a burdensome ongoing problem |
| 5. | arduousness | great difficulty or effort |
| 6. | awkwardness | difficulty in handling smoothly |
| 7. | bane | a persistent source of trouble |
| 8. | barrier | something that prevents progress |
| 9. | bind | a difficult situation |
| 10. | blockage | something causing obstruction |
| 11. | bottleneck | a point causing delay |
| 12. | burden | a heavy or difficult load |
| 13. | challenge | a demanding task or situation |
| 14. | chaos | complete disorder and trouble |
| 15. | complexity | the state of being complicated |
| 16. | complication | something that makes matters harder |
| 17. | confusion | lack of clarity causing trouble |
| 18. | constraint | a limiting difficulty |
| 19. | crisis | a time of intense trouble |
| 20. | crunch | a critical difficult moment |
| 21. | deadlock | a standstill from opposition |
| 22. | delicacy | difficulty requiring careful handling |
| 23. | demand | a difficult requirement |
| 24. | disruption | interference causing trouble |
| 25. | distress | extreme trouble or suffering |
| 26. | drawback | a disadvantage or hindrance |
| 27. | encumbrance | something that burdens or hinders |
| 28. | entanglement | a complicated difficult involvement |
| 29. | exigency | urgent difficult need |
| 30. | fetter | a restraint or hindrance |
| 31. | fix | a troublesome predicament |
| 32. | formidability | impressive difficult quality |
| 33. | friction | resistance that complicates action |
| 34. | frustration | trouble causing disappointment |
| 35. | glitch | a small unexpected problem |
| 36. | gridlock | a complete standstill |
| 37. | hard time | a period of difficulty |
| 38. | hardship | severe difficulty or suffering |
| 39. | hazard | a source of danger or trouble |
| 40. | headache | a troublesome problem |
| 41. | hindrance | something that delays progress |
| 42. | hurdle | an obstacle to overcome |
| 43. | impediment | something that hinders action |
| 44. | inconvenience | minor trouble or bother |
| 45. | interference | action that hinders progress |
| 46. | intractability | hardness to manage or solve |
| 47. | intricacy | complex difficult detail |
| 48. | issue | a matter causing trouble |
| 49. | jam | a tight difficult situation |
| 50. | kink | a small problem to solve |
| 51. | liability | a source of disadvantage |
| 52. | limitation | a restricting condition |
| 53. | logjam | a blockage causing delay |
| 54. | millstone | a heavy burden or hindrance |
| 55. | minefield | a situation full of hazards |
| 56. | misery | great discomfort or distress |
| 57. | muddle | a confused troublesome state |
| 58. | nightmare | a very troublesome situation |
| 59. | nuisance | a bothersome problem |
| 60. | obstacle | something that blocks progress |
| 61. | obstruction | something that blocks movement |
| 62. | onerousness | the quality of being burdensome |
| 63. | oppressiveness | crushing burdensome quality |
| 64. | ordeal | a painful difficult experience |
| 65. | pain | something bothersome or troublesome |
| 66. | pickle | a troublesome situation |
| 67. | pinch | a difficult or needy situation |
| 68. | plight | an unfortunate difficult condition |
| 69. | predicament | a difficult awkward situation |
| 70. | pressure | stressful demand or burden |
| 71. | problem | something hard to deal with |
| 72. | quandary | a state of uncertainty |
| 73. | resistance | opposition making progress harder |
| 74. | rigor | strictness or demanding difficulty |
| 75. | roadblock | an obstacle stopping progress |
| 76. | rough going | progress that is difficult |
| 77. | rough patch | a period of trouble |
| 78. | rub | the difficult part |
| 79. | setback | a reversal causing trouble |
| 80. | snag | a small unexpected problem |
| 81. | snarl | a tangled difficult problem |
| 82. | stalemate | a situation with no progress |
| 83. | sticky situation | a tricky difficult situation |
| 84. | stress | mental or emotional strain |
| 85. | struggle | a hard effort or conflict |
| 86. | stumbling block | something that impedes progress |
| 87. | tangle | a confused difficult situation |
| 88. | tight spot | a difficult situation |
| 89. | toughness | the quality of being hard |
| 90. | trap | a confining difficult situation |
| 91. | trial | a difficult experience |
| 92. | tribulation | great suffering or trouble |
| 93. | trouble | difficulty or distress |
| 94. | turmoil | great disturbance and trouble |
| 95. | unwieldiness | difficulty in handling |
| 96. | upheaval | major disruptive trouble |
| 97. | uphill battle | a very hard struggle |
| 98. | vexation | annoying trouble or frustration |
| 99. | woe | great trouble or distress |
| 100. | yoke | a burden or restraint |
