| No. | Item | Definition |
|---|---|---|
| 1. | Achilles’ heel | a serious hidden weakness |
| 2. | adverse factor | a condition working against success |
| 3. | adversity | serious difficulty or misfortune |
| 4. | affliction | a cause of pain or hardship |
| 5. | albatross | a persistent burden or handicap |
| 6. | bane | a cause of trouble or ruin |
| 7. | barrier | something preventing progress or access |
| 8. | bind | a difficult restrictive situation |
| 9. | blemish | a small fault or imperfection |
| 10. | blind spot | an unnoticed weakness or limitation |
| 11. | block | an obstacle or obstruction |
| 12. | bottleneck | a point causing delay or restriction |
| 13. | burden | a heavy difficulty or responsibility |
| 14. | catch | a hidden drawback or condition |
| 15. | check | a restraint or obstacle |
| 16. | complication | a factor making things harder |
| 17. | con | an argument or point against |
| 18. | constraint | a restriction limiting action or success |
| 19. | cost | a negative consequence or sacrifice |
| 20. | curb | a restraint or limitation |
| 21. | curse | a severe burden or misfortune |
| 22. | damage | harm that reduces value or usefulness |
| 23. | danger | a possibility of harm or loss |
| 24. | defect | a flaw or imperfection |
| 25. | deterrent | something discouraging action or choice |
| 26. | detriment | harm or damage caused by something |
| 27. | difficulty | something hard to deal with |
| 28. | disincentive | something discouraging a decision or action |
| 29. | downside | the negative side of something |
| 30. | drag | something slowing progress or success |
| 31. | drawback | a negative feature or limitation |
| 32. | encumbrance | something that burdens or restricts |
| 33. | exposure | vulnerability to risk or loss |
| 34. | failing | a weakness or deficiency |
| 35. | failure point | a vulnerable point of breakdown |
| 36. | fault | a defect or weakness |
| 37. | fetter | a restraint or limitation |
| 38. | flaw | a fault reducing value or quality |
| 39. | fly in the ointment | a flaw spoiling something good |
| 40. | foible | a minor weakness or failing |
| 41. | frailty | a weakness or lack of strength |
| 42. | gap | a missing or weak part |
| 43. | glitch | a minor fault or problem |
| 44. | handicap | something that makes success harder |
| 45. | hardship | a severe difficulty or deprivation |
| 46. | harm | damage or negative effect |
| 47. | hazard | a source of danger or risk |
| 48. | headwind | a force working against progress |
| 49. | hindrance | something that delays or obstructs |
| 50. | hitch | a temporary problem or snag |
| 51. | hurdle | a difficulty to overcome |
| 52. | ill | a harm or misfortune |
| 53. | impairment | a reduced ability or function |
| 54. | impediment | something that hinders progress |
| 55. | imperfection | a fault or incomplete quality |
| 56. | inadequacy | a lack of necessary quality |
| 57. | inferiority | lower quality or status |
| 58. | injury | harm or damage suffered |
| 59. | insufficiency | an inadequate amount or quality |
| 60. | kink | a problem needing correction |
| 61. | lack | an absence of something needed |
| 62. | liability | a thing causing problems or risk |
| 63. | limitation | a restriction or limiting factor |
| 64. | limiting factor | something that restricts success |
| 65. | loss | something lost or a negative result |
| 66. | millstone | a heavy burden or disadvantage |
| 67. | minus | a negative point or factor |
| 68. | negative | a bad point or aspect |
| 69. | obstacle | something blocking progress or success |
| 70. | obstruction | something that blocks or hinders |
| 71. | odds against | unfavorable chances of success |
| 72. | penalty | a disadvantage imposed or suffered |
| 73. | pitfall | a hidden danger or drawback |
| 74. | plague | a persistent source of trouble |
| 75. | predicament | a difficult or unpleasant situation |
| 76. | pressure | a burdening force or difficulty |
| 77. | problem | a difficulty or unfavorable condition |
| 78. | restraint | something that limits action |
| 79. | restriction | a limiting condition or rule |
| 80. | risk | a chance of harm or loss |
| 81. | roadblock | an obstacle preventing progress |
| 82. | scarcity | a shortage or limited availability |
| 83. | setback | a reversal or loss of progress |
| 84. | shortage | an insufficient amount or supply |
| 85. | shortcoming | a fault or deficiency |
| 86. | shortfall | an amount below what is needed |
| 87. | snag | a hidden problem or difficulty |
| 88. | soft spot | a vulnerable point or weakness |
| 89. | strain | a pressure or burden |
| 90. | stumbling block | a major obstacle or difficulty |
| 91. | trouble | a problem or source of difficulty |
| 92. | unfavorable factor | a factor that creates difficulty |
| 93. | vice | a bad habit or fault |
| 94. | vulnerability | a weakness open to harm |
| 95. | want | a lack or deficiency |
| 96. | weak link | the weakest or riskiest part |
| 97. | weak spot | a vulnerable or deficient area |
| 98. | weakness | a limiting or vulnerable point |
| 99. | weight | a burden or disadvantage |
| 100. | wrinkle | a minor problem or complication |