| No. | Item | Definition |
|---|---|---|
| 1. | adverse fortune | unfavorable fate or luck |
| 2. | affliction | something causing pain or hardship |
| 3. | albatross | a burdensome problem |
| 4. | bad luck | unfortunate chance |
| 5. | bad times | periods of hardship |
| 6. | battle | a difficult struggle |
| 7. | bind | a difficult situation |
| 8. | bitter trial | a very painful test |
| 9. | blow | a damaging setback |
| 10. | burden | a heavy hardship or load |
| 11. | calamity | a disastrous event or hardship |
| 12. | catastrophe | a sudden great disaster |
| 13. | collapse | sudden failure or breakdown |
| 14. | conflict | serious disagreement or struggle |
| 15. | crisis | a time of intense difficulty |
| 16. | cross | a burden or hardship |
| 17. | curse | a source of suffering |
| 18. | danger | risk of harm |
| 19. | defeat | loss or setback |
| 20. | deprivation | lack of basic necessities |
| 21. | desolation | misery and bleak emptiness |
| 22. | destitution | extreme poverty and need |
| 23. | difficulty | a condition that is hard |
| 24. | disaster | a terrible damaging event |
| 25. | distress | extreme pain or hardship |
| 26. | emergency | a sudden serious difficulty |
| 27. | encumbrance | a burden or hindrance |
| 28. | evil days | times of trouble or hardship |
| 29. | exigency | an urgent difficult situation |
| 30. | extremity | severe difficulty or danger |
| 31. | failure | lack of success or collapse |
| 32. | fight | a hard struggle |
| 33. | fix | a difficult predicament |
| 34. | frustration | disappointment from difficulty |
| 35. | grief | deep sorrow or suffering |
| 36. | grinding hardship | severe ongoing difficulty |
| 37. | hard going | progress marked by difficulty |
| 38. | hard knocks | painful life difficulties |
| 39. | hard row | a difficult situation |
| 40. | hard time | a period of difficulty |
| 41. | hardship | severe difficulty or suffering |
| 42. | hell | an extremely painful situation |
| 43. | hindrance | something causing delay or difficulty |
| 44. | ill fortune | bad luck or misfortune |
| 45. | ill luck | bad luck |
| 46. | impediment | something that obstructs progress |
| 47. | indigence | poverty or need |
| 48. | jam | a difficult situation |
| 49. | jeopardy | danger of loss or harm |
| 50. | load | a burden to bear |
| 51. | loss | deprivation or disadvantage |
| 52. | low ebb | a state of decline |
| 53. | millstone | a heavy burden |
| 54. | misery | great suffering or discomfort |
| 55. | misfortune | bad luck or suffering |
| 56. | nightmare | a very distressing experience |
| 57. | obstacle | something that blocks progress |
| 58. | opposition | active resistance or obstacle |
| 59. | oppression | cruel hardship or pressure |
| 60. | ordeal | a painful or difficult experience |
| 61. | peril | serious danger or risk |
| 62. | persecution | hostile mistreatment and suffering |
| 63. | pickle | a troublesome situation |
| 64. | plague | a persistent source of trouble |
| 65. | poverty | extreme lack of money |
| 66. | predicament | a difficult, unpleasant situation |
| 67. | pressure | burdensome demand or stress |
| 68. | privation | lack causing hardship |
| 69. | quandary | a state of uncertainty |
| 70. | reversal | a change for the worse |
| 71. | reverse | an unfavorable change of fortune |
| 72. | rough going | difficult progress or conditions |
| 73. | rough patch | a difficult period |
| 74. | rough sledding | a difficult course |
| 75. | ruin | complete destruction or collapse |
| 76. | ruination | complete ruin or destruction |
| 77. | scourge | a cause of great suffering |
| 78. | setback | a reversal or difficulty |
| 79. | sore trial | a painful test |
| 80. | storm | a turbulent difficult period |
| 81. | strife | bitter conflict or struggle |
| 82. | struggle | a hard effort against difficulty |
| 83. | stumbling block | an obstacle or difficulty |
| 84. | suffering | pain, hardship, or distress |
| 85. | tempest | violent trouble or turmoil |
| 86. | tight spot | a difficult situation |
| 87. | tragedy | a very sad event |
| 88. | trial | a difficult test or experience |
| 89. | tribulation | great suffering or trouble |
| 90. | trouble | a state of problems |
| 91. | trying time | a period of hardship |
| 92. | turmoil | great disturbance or trouble |
| 93. | undoing | cause of ruin or downfall |
| 94. | unease | anxious discomfort or trouble |
| 95. | upheaval | violent disturbance or difficulty |
| 96. | uphill battle | a very difficult struggle |
| 97. | victimization | unfair treatment causing suffering |
| 98. | woe | great sorrow or distress |
| 99. | woefulness | great sorrow or misery |
| 100. | wretchedness | extreme misery or unhappiness |