| No. | Item | Definition |
|---|---|---|
| 1. | abrasive | wearing down or harsh |
| 2. | adverse | unfavorable or harmful |
| 3. | antagonistic | opposed and harmful or hostile |
| 4. | awful | very bad or harmful |
| 5. | bad | harmful or undesirable |
| 6. | baleful | threatening harm or evil |
| 7. | baneful | causing harm or ruin |
| 8. | blighting | spoiling or damaging severely |
| 9. | brutal | extremely harsh or damaging |
| 10. | burdensome | causing difficulty or strain |
| 11. | calamitous | causing disaster or great harm |
| 12. | carcinogenic | capable of causing cancer |
| 13. | catastrophic | causing disastrous damage |
| 14. | contaminating | making unsafe or impure |
| 15. | corrosive | gradually destructive or harmful |
| 16. | costly | causing loss or expense |
| 17. | counterproductive | having the opposite desired effect |
| 18. | crippling | severely damaging or weakening |
| 19. | damaging | causing damage or loss |
| 20. | damnatory | strongly damaging or condemning |
| 21. | dangerous | likely to cause harm |
| 22. | debilitating | making weak or impaired |
| 23. | deleterious | harmful, especially gradually |
| 24. | depleting | using up or reducing |
| 25. | destructive | causing serious damage |
| 26. | disabling | causing inability or impairment |
| 27. | draining | depleting energy or resources |
| 28. | enfeebling | making weak or feeble |
| 29. | erosive | gradually wearing away |
| 30. | evil | morally bad or harmful |
| 31. | fatal | causing death or complete failure |
| 32. | grave | serious and potentially harmful |
| 33. | harmful | causing harm or damage |
| 34. | harsh | severe, cruel, or damaging |
| 35. | hazardous | dangerous or risky |
| 36. | horrible | very bad or unpleasant |
| 37. | hostile | unfriendly or harmful |
| 38. | hurtful | causing emotional or physical harm |
| 39. | ill | bad or harmful |
| 40. | impairing | making worse or weaker |
| 41. | inimical | hostile or harmful |
| 42. | injurious | causing injury or harm |
| 43. | insalubrious | unhealthy or harmful |
| 44. | lethal | able to cause death |
| 45. | libelous | written and reputationally damaging |
| 46. | life-threatening | likely to cause death |
| 47. | loss-making | causing financial losses |
| 48. | malefic | causing evil or harm |
| 49. | maleficent | harmful or evil in intent |
| 50. | malevolent | wishing or causing harm |
| 51. | malicious | intending or causing harm |
| 52. | malignant | very harmful or dangerous |
| 53. | marring | spoiling appearance or quality |
| 54. | mortal | causing death or fatal harm |
| 55. | mutagenic | causing genetic mutation |
| 56. | nasty | unpleasant or harmful |
| 57. | negative | harmful or unfavorable in effect |
| 58. | noxious | harmful, poisonous, or unpleasant |
| 59. | onerous | very burdensome or difficult |
| 60. | oppressive | harshly burdensome or harmful |
| 61. | pathogenic | causing disease |
| 62. | perilous | full of danger |
| 63. | pernicious | very harmful, often subtly |
| 64. | poisonous | toxic or harmful |
| 65. | polluting | making harmful or impure |
| 66. | prejudicial | causing disadvantage or harm |
| 67. | problematic | causing problems or concern |
| 68. | risky | involving possible harm |
| 69. | ruinous | causing ruin or severe damage |
| 70. | sapping | gradually draining strength |
| 71. | scarring | leaving lasting damage |
| 72. | serious | significant and potentially harmful |
| 73. | severe | very serious or damaging |
| 74. | sinister | threatening harm or evil |
| 75. | spoiling | damaging quality or usefulness |
| 76. | staining | damaging reputation or appearance |
| 77. | sullying | spoiling purity or reputation |
| 78. | tainting | spoiling purity or reputation |
| 79. | tarnishing | damaging reputation or shine |
| 80. | taxing | requiring harmful effort or strain |
| 81. | teratogenic | causing birth defects |
| 82. | terminal | ending in death or failure |
| 83. | terrible | very bad or harmful |
| 84. | toxic | poisonous or deeply harmful |
| 85. | treacherous | dangerous and unpredictable |
| 86. | undermining | weakening gradually or secretly |
| 87. | undesirable | not wanted or beneficial |
| 88. | unfavorable | not beneficial or supportive |
| 89. | unfortunate | bringing bad consequences |
| 90. | unhealthy | harmful to health |
| 91. | unhelpful | not useful or beneficial |
| 92. | unsafe | not safe; risky |
| 93. | unwholesome | not healthy or morally good |
| 94. | venomous | poisonous or malicious |
| 95. | vicious | cruel, violent, or harmful |
| 96. | virulent | extremely harmful or hostile |
| 97. | wasteful | using resources harmfully or inefficiently |
| 98. | weakening | making less strong |
| 99. | wicked | morally bad or harmful |
| 100. | worsening | making something worse |