| No. | Item | Definition |
|---|---|---|
| 1. | adversities | serious misfortunes or hardships |
| 2. | adversity | a difficult or unlucky situation |
| 3. | affliction | something causing pain or distress |
| 4. | afflictions | things causing pain or distress |
| 5. | albatross | a burdensome ongoing problem |
| 6. | anguish | severe mental or physical pain |
| 7. | bane | a cause of misery |
| 8. | baptism of fire | a difficult first experience |
| 9. | barrier | something blocking movement or progress |
| 10. | battle | a hard fight or effort |
| 11. | bind | a difficult situation |
| 12. | bottleneck | a point causing delay |
| 13. | burden | a heavy trouble or duty |
| 14. | catch | a hidden problem or drawback |
| 15. | challenge | a demanding task or situation |
| 16. | challenges | demanding situations requiring effort |
| 17. | complication | something that makes matters harder |
| 18. | complications | factors making something harder |
| 19. | conflict | serious disagreement or struggle |
| 20. | crisis | a time of intense difficulty |
| 21. | cross to bear | a persistent burden or trouble |
| 22. | dead end | a situation with no progress |
| 23. | difficulties | things that are hard to handle |
| 24. | difficulty | a condition of being hard |
| 25. | disarray | a state of disorder |
| 26. | disruption | interruption causing problems |
| 27. | drag | something that slows progress |
| 28. | drawback | a disadvantage or problem |
| 29. | effort | serious attempt using energy |
| 30. | encumbrance | a burden or hindrance |
| 31. | exertion | great physical or mental effort |
| 32. | fight | a determined effort against difficulty |
| 33. | fix | a difficult predicament |
| 34. | fray | a noisy fight or conflict |
| 35. | friction | conflict causing difficulty |
| 36. | frustration | annoyance from blocked efforts |
| 37. | grapple | a struggle to handle something |
| 38. | grind | hard dull continuous work |
| 39. | hard row to hoe | a very difficult situation |
| 40. | hard time | a period of difficulty |
| 41. | hardships | severe difficulties or suffering |
| 42. | havoc | great confusion or damage |
| 43. | headwind | force making progress harder |
| 44. | hindrance | something that delays progress |
| 45. | hurdle | a difficult barrier |
| 46. | hurdles | difficult barriers to overcome |
| 47. | impediment | something that obstructs progress |
| 48. | issue | an important problem |
| 49. | issues | important problems or concerns |
| 50. | jam | a difficult or awkward situation |
| 51. | labor | hard physical or mental work |
| 52. | load | a heavy burden or demand |
| 53. | melee | a confused fight or struggle |
| 54. | mess | a difficult confused situation |
| 55. | millstone | a heavy burden or hindrance |
| 56. | obstacle | something that blocks progress |
| 57. | obstacles | things blocking progress or action |
| 58. | ordeal | a painful difficult experience |
| 59. | ordeals | severely trying experiences |
| 60. | pickle | a troublesome situation |
| 61. | plight | a difficult unfortunate situation |
| 62. | poverty | state of extreme lack |
| 63. | predicament | a difficult awkward situation |
| 64. | predicaments | difficult or unpleasant situations |
| 65. | privation | lack causing hardship |
| 66. | problem | a matter needing a solution |
| 67. | problems | matters causing trouble or concern |
| 68. | quandary | a state of uncertainty |
| 69. | roadblock | something stopping progress |
| 70. | rocky road | a difficult course ahead |
| 71. | rough going | progress that is difficult |
| 72. | rough patch | a difficult period |
| 73. | rough spot | a difficult point or period |
| 74. | rub | the difficult part of something |
| 75. | ruckus | a noisy disturbance or trouble |
| 76. | scramble | a hurried struggle to cope |
| 77. | scuffle | a short confused fight |
| 78. | setback | a reversal or delay |
| 79. | setbacks | delays or reverses in progress |
| 80. | skirmish | a minor conflict or clash |
| 81. | snag | a small unexpected difficulty |
| 82. | snags | small unexpected problems |
| 83. | strife | bitter conflict or struggle |
| 84. | trial | a testing experience |
| 85. | trials | painful or testing experiences |
| 86. | tribulation | great suffering or trouble |
| 87. | tribulations | great troubles or suffering |
| 88. | trouble | difficulty or problems |
| 89. | troubles | difficulties or distressing matters |
| 90. | turmoil | great disturbance or confusion |
| 91. | tussle | a brief struggle or fight |
| 92. | uphill battle | a very difficult effort |
| 93. | uproar | a state of noisy disorder |
| 94. | upset | disturbance causing difficulty |
| 95. | weight | a burden or pressure |
| 96. | woe | great sorrow or trouble |
| 97. | woes | great sorrows or troubles |
| 98. | worry | anxiety about problems |
| 99. | wrestle | a hard effort to deal |
| 100. | yoke | a heavy burden or restraint |